Multiple basal promoter elements determine the level of human c-fos transcription.
نویسندگان
چکیده
منابع مشابه
Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements
Transcription control regions of eukaryotic genes contain multiple sequence elements proposed to function independently to regulate transcription. We developed transgenic mice carrying fos-lacZ fusion genes with clustered point mutations in each of several distinct regulatory sequences: the sis-inducible element, the serum response element, the fos AP-1 site, and the calcium/cAMP response eleme...
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Transcription of the human HSP70 gene is regulated by a complex array of cis-acting promoter elements that respond to conditions that include normal conditions of cell growth and induction following physiological stress. We have examined the requirements of the basal and inducible promoter elements by using promoter mutations and a transient transfection assay. Multiple forms of stress-induced ...
متن کاملSignal integration at the c-fos promoter.
The c-fos gene encodes a basic region-leucine zipper transcription factor that requires heterodimerization with a member of the Jun family for stable DNA binding. Fos/Jun heterodimers are present in the AP-1 transcription factor complex and both c-Fos and c-Jun are capable of transforming cells (1). Continuous expression of c-fos can lead to aberrant differentiation (2) but may also sometimes b...
متن کاملRepression of the basal c-fos promoter by wild-type p53.
Mutations in the p53 gene are the most common genetic alterations observed in many inherited and sporadic forms of human cancer. Recent studies indicate that wild-type p53 may be involved in the regulation of gene expression. In the present report we examined the effect of p53 on the human c-fos promoter. Using a transient co-transfection assay we show that wild-type human p53, but not a transf...
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We previously observed that the trophic actions of gastrin (G17) on the AR42J rat acinar cell line are mediated by mitogen-activated protein kinase (MAPK)-induced c-fos gene transcription via protein kinase C (PKC)-dependent and -independent pathways. In this study, we further investigated the signaling pathways that target c-fos in response to G17. G17 led to a sixfold induction in luciferase ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1991
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.11.3.1270